Note that RanBP1 (1K5D_B) does not have a very high sequence identity
to its
unbound equivalent, which happens to be RanBP2. They have very
similar structures.
RanBP does not directly interact with RanGAP and is included for
completeness.
NOTE THAT IN THE ALIGNMENTS BELOW, GAPS MOST LIKELY INDICATE
RESIDUES MISSING IN THE ELECTRON DENSITY.
Alignment: 1K5D_A against 1RRP_A
Query=
(206 letters)
>1RRP_A
Length = 204
Score = 422 bits (1084), Expect = e-123
Identities = 204/204 (100%), Positives = 204/204 (100%)
Query: 1 QVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTA 60
QVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTA
Sbjct: 1 QVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTA 60
Query: 61 GQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIK 120
GQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIK
Sbjct: 61 GQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIK 120
Query: 121 DRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEV 180
DRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEV
Sbjct: 121 DRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEV 180
Query: 181 VMDPALAAQYEHDLEVAQTTALPD 204
VMDPALAAQYEHDLEVAQTTALPD
Sbjct: 181 VMDPALAAQYEHDLEVAQTTALPD 204
Alignment: 1K5D_B against 1RRP_B
Query=
(146 letters)
>1RRP_B
Length = 134
Score = 165 bits (418), Expect = 2e-46
Identities = 86/134 (64%), Positives = 103/134 (76%), Gaps = 4/134 (2%)
Query: 6 FEPIVSLPEQ-EIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGA 64
FEP+V LP++ E+KT EEDEEE F RAKLFRF E+ EWKERG G+VK+L+HK G
Sbjct: 2 FEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDVESK--EWKERGIGNVKILRHKTSGK 59
Query: 65 IRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNA 124
IRLLMRR++ LKICANHYI+P M+L PNAGSDR++VW+ D+ADE PKPE LAIRF
Sbjct: 60 IRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHA-LDYADELPKPEQLAIRFKTP 118
Query: 125 ENAQKFKTKFEECR 138
E A FK KFEE +
Sbjct: 119 EEAALFKCKFEEAQ 132
Alignment: 1K5D_C against 1YRG_B
Query=
(344 letters)
>1YRG_B
Length = 343
Score = 672 bits (1733), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 ARFSIEGKSLKLDAITTEDEKSVFAVLLEDDSVKEIVLSGNTIGTEAARWLSENIASKKD 60
ARFSIEGKSLKLDAITTEDEKSVFAVLLEDDSVKEIVLSGNTIGTEAARWLSENIASKKD
Sbjct: 1 ARFSIEGKSLKLDAITTEDEKSVFAVLLEDDSVKEIVLSGNTIGTEAARWLSENIASKKD 60
Query: 61 LEIAEFSDIFTGRVKDEIPEALRLLLQALLKCPKLHTVRLSDNAFGPTAQEPLIDFLSKH 120
LEIAEFSDIFTGRVKDEIPEALRLLLQALLKCPKLHTVRLSDNAFGPTAQEPLIDFLSKH
Sbjct: 61 LEIAEFSDIFTGRVKDEIPEALRLLLQALLKCPKLHTVRLSDNAFGPTAQEPLIDFLSKH 120
Query: 121 TPLEHLYLHNNGLGPQAGAKIARALQELAVNKKAKNAPPLRSIICGRNRLENGSMKEWAK 180
TPLEHLYLHNNGLGPQAGAKIARALQELAVNKKAKNAPPLRSIICGRNRLENGSMKEWAK
Sbjct: 121 TPLEHLYLHNNGLGPQAGAKIARALQELAVNKKAKNAPPLRSIICGRNRLENGSMKEWAK 180
Query: 181 TFQSHRLLHTVKMVQNGIRPEGIEHLLLEGLAYCQELKVLDLQDNTFTHLGSSALAIALK 240
TFQSHRLLHTVKMVQNGIRPEGIEHLLLEGLAYCQELKVLDLQDNTFTHLGSSALAIALK
Sbjct: 181 TFQSHRLLHTVKMVQNGIRPEGIEHLLLEGLAYCQELKVLDLQDNTFTHLGSSALAIALK 240
Query: 241 SWPNLRELGLNDCLLSARGAAAVVDAFSKLENIGLQTLRLQYNEIELDAVRTLKTVIDEK 300
SWPNLRELGLNDCLLSARGAAAVVDAFSKLENIGLQTLRLQYNEIELDAVRTLKTVIDEK
Sbjct: 241 SWPNLRELGLNDCLLSARGAAAVVDAFSKLENIGLQTLRLQYNEIELDAVRTLKTVIDEK 300
Query: 301 MPDLLFLELNGNRFSEEDDVVDEIREVFSTRGRGELDELDDME 343
MPDLLFLELNGNRFSEEDDVVDEIREVFSTRGRGELDELDDME
Sbjct: 301 MPDLLFLELNGNRFSEEDDVVDEIREVFSTRGRGELDELDDME 343