The gamma subunits in bound and unbound structures are different variants within
the G-protein gamma family. The sequence identity is quite low, but the structures are
very similar. Most of the interaction occurs between the alpha and beta subunits and
the gamma subunit was included for completeness.

NOTE THAT IN THE ALIGNMENTS BELOW, GAPS MOST LIKELY INDICATE
RESIDUES MISSING IN THE ELECTRON DENSITY.

Alignment: 1GP2_A against 1GIA_
Query= 
         (344 letters)

>1GIA_
          Length = 310

 Score =  625 bits (1612), Expect = 0.0
 Identities = 310/310 (100%), Positives = 310/310 (100%)

Query: 30  VKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKI 89
           VKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKI
Sbjct: 1   VKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKI 60

Query: 90  DFGDAARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAA 149
           DFGDAARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAA
Sbjct: 61  DFGDAARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAA 120

Query: 150 YYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIH 209
           YYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIH
Sbjct: 121 YYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIH 180

Query: 210 CFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDL 269
           CFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDL
Sbjct: 181 CFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDL 240

Query: 270 FEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQ 329
           FEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQ
Sbjct: 241 FEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQ 300

Query: 330 FVFDAVTDVI 339
           FVFDAVTDVI
Sbjct: 301 FVFDAVTDVI 310


Alignment: 1GP2_B against 1TBG_D
Query= 
         (339 letters)

>1TBG_D
          Length = 340

 Score =  702 bits (1811), Expect = 0.0
 Identities = 339/339 (100%), Positives = 339/339 (100%)

Query: 1   SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 60
           SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM
Sbjct: 2   SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAM 61

Query: 61  HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC 120
           HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC
Sbjct: 62  HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC 121

Query: 121 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 180
           SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT
Sbjct: 122 SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFT 181

Query: 181 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 240
           GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF
Sbjct: 182 GHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF 241

Query: 241 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 300
           ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK
Sbjct: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301

Query: 301 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 339
           ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Sbjct: 302 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340


Alignment: 1GP2_G against 1TBG_H
Query= 
         (54 letters)

>1TBG_H
          Length = 65

 Score = 43.5 bits (101), Expect = 2e-10
 Identities = 19/46 (41%), Positives = 28/46 (60%)

Query: 9  VEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPF 54
          V+QLK E  ++R+ VSK   +   Y E  + EDPL+  +P  +NPF
Sbjct: 19 VDQLKKEVTLERMLVSKCCEEFRDYVEERSGEDPLVKGIPEDKNPF 64