The Erythropoietin Receptor is a homodimer, anchored in the membrane. The membrane
portion of the molecule is missing. The homodimer binds the Erythropoietin asymmetrically,
in fact what most likely happens is that the binding causes the receptor to dimerize.

This benchmark case can be considered quasi-bound because we used the bound complex
structure to superpose two unbound receptor molecules and thus simulate the bound state of the
receptor.

NOTE THAT IN THE ALIGNMENTS BELOW, GAPS MOST LIKELY INDICATE
RESIDUES MISSING IN THE ELECTRON DENSITY.

Alignment: 1EER_A against 1BUY_A
Query= 
         (166 letters)

>1BUY_A
          Length = 166

 Score =  324 bits (831), Expect = 4e-94
 Identities = 164/166 (98%), Positives = 164/166 (98%)

Query: 1   APPRLICDSRVLERYLLEAKEAEKITTGCAEHCSLNEKITVPDTKVNFYAWKRMEVGQQA 60
           APPRLICDSRVLERYLLEAKEAEKITTGCAEHCSLNEKITVPDTKVNFYAWKRMEVGQQA
Sbjct: 1   APPRLICDSRVLERYLLEAKEAEKITTGCAEHCSLNEKITVPDTKVNFYAWKRMEVGQQA 60

Query: 61  VEVWQGLALLSEAVLRGQALLVKSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAIS 120
           VEVWQGLALLSEAVLRGQALLVKSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAIS
Sbjct: 61  VEVWQGLALLSEAVLRGQALLVKSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAIS 120

Query: 121 NSDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR 166
             DAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR
Sbjct: 121 PPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR 166


Alignment: 1EER_B against 1ERN_A
Query= 
         (213 letters)

>1ERN_A
          Length = 207

 Score =  403 bits (1035), Expect = e-117
 Identities = 204/211 (96%), Positives = 204/211 (96%), Gaps = 5/211 (2%)

Query: 3   KFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGQYSFSYQLEDEPWKLCRL 62
           KFESKAALLAA   EELLCFTERLEDLVCFWEEAASAGVGPG YSFSYQLEDEPWKLCRL
Sbjct: 1   KFESKAALLAA---EELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRL 57

Query: 63  HQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVA 122
           HQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVA
Sbjct: 58  HQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVA 117

Query: 123 RLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGQGAGSVQRVEILEGRTECVLSNLRGR 182
           RLADE GHVVLRWLPPPETPMTSHIRYEVDVSAG GAGSVQRVEILEGRTECVLSNLRGR
Sbjct: 118 RLADE-GHVVLRWLPPPETPMTSHIRYEVDVSAG-GAGSVQRVEILEGRTECVLSNLRGR 175

Query: 183 TRYTFAVRARMAEPSFGGFWSEWSEPVSLLT 213
           TRYTFAVRARMAEPSFGGFWS WSEPVSLLT
Sbjct: 176 TRYTFAVRARMAEPSFGGFWSAWSEPVSLLT 206


Alignment: 1EER_C against 1ERN_B
Query= 
         (213 letters)

>1ERN_B
          Length = 209

 Score =  409 bits (1051), Expect = e-119
 Identities = 205/211 (97%), Positives = 205/211 (97%), Gaps = 4/211 (1%)

Query: 3   KFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGQYSFSYQLEDEPWKLCRL 62
           KFESKAALLAA   EELLCFTERLEDLVCFWEEAASAGVGPG YSFSYQLEDEPWKLCRL
Sbjct: 1   KFESKAALLAA---EELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRL 57

Query: 63  HQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVA 122
           HQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVA
Sbjct: 58  HQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVA 117

Query: 123 RLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGQGAGSVQRVEILEGRTECVLSNLRGR 182
           RLADESGHVVLRWLPPPETPMTSHIRYEVDVSAG GAGSVQRVEILEGRTECVLSNLRGR
Sbjct: 118 RLADESGHVVLRWLPPPETPMTSHIRYEVDVSAG-GAGSVQRVEILEGRTECVLSNLRGR 176

Query: 183 TRYTFAVRARMAEPSFGGFWSEWSEPVSLLT 213
           TRYTFAVRARMAEPSFGGFWS WSEPVSLLT
Sbjct: 177 TRYTFAVRARMAEPSFGGFWSAWSEPVSLLT 207